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KMID : 1134820140430060799
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 6 p.799 ~ p.806
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Anti-amnesic Effect of Eriobotrya japonica Leaf Extract on Scopolamine-induced Memory Impairment in Rats
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Bae Dong-Hyuck
Kim Ji-Hye
Na Ju-Ryun
Kim Yu-Jin
Lee Joon-Yeol
Kim Sun-Oh
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Abstract
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The present study was conducted to evaluate the effects of extract from Eriobotrya japonica leaves (EJE) on cognitive impairment induced by scopolamine, a muscarinic antagonist, in rats. Scopolamine injection (1 mg/kg, i.p.) impaired performance in rats in the passive avoidance test as well as in water maze test and severely reduced cholinergic system reactivity, as indicated by reduced acetylcholine levels and increased acetylcholinesterase activity. Daily administration of EJE significantly increased step-through latency in the passive avoidance test, reduced escape latency, and increased time spent in the platform quadrant in the Morris water maze test. EJE protected against scopolamine-induced cholinergic system deficit, including reduced acetylcholine levels and increased acetylcholinesterase activity in whole brain homogenates. These results suggest that EJE provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.
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KEYWORD
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anti-amnesia, scopolamine, cognitive impairment, Eriobotrya japonica
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